Dr. Iyanuoluwa Odole: Championing global health and cancer research for African populations

With her academic roots in clinical dentistry from the University of Ibadan and a Master of Public Health in Epidemiology & Global Health from Yale University, Dr. Odole has quickly established herself as a leading voice in cancer epidemiology. She is at the forefront of crucial research aimed at addressing cancer risks among African-descent populations.

Dr. Odole’s work is distinguished not only by its scientific rigor but by its humanitarian impact. She has played an instrumental role in advancing the representation of African genomic data in cancer research, developing digital health interventions for breast and lung cancer screenings, and advocating for greater health equity in underserved communities. Her commitment to improving breast cancer care in Africa through partnerships with organizations like the Breast Cancer Association of Nigeria (BRECAN) has earned her widespread recognition, including the prestigious Margaret McNamara Award.

In this exclusive interview, Dr. Odole shares her remarkable journey from dentistry to global public health, reflecting on the challenges of cancer research, the importance of technological innovation, and her vision for advancing healthcare equity for African populations worldwide. Excerpts:

Could you share insights into your upbringing in Nigeria and the factors that inspired your pursuit of a career combining public health and dentistry?

After Medical School, I took a non-traditional path by working for a biotechnology company focused on African genomic data and addressing the underrepresentation of the African population in global genomics research. It was interesting to find out that only 2% of data used in available genome-wide association studies are of African ancestry despite the rich genetic diversity of African populations. This opened my eyes to global health research’s broader, systemic gaps. Although I trained as a dental surgeon, I became more interested in bridging this gap and improving population health for the African population alongside the one-on-one clinical service and care I was providing to my patients.

Your academic trajectory from the University of Ibadan to Yale is impressive. What led you to Yale, and how has this experience shaped your research focus and career goals?

My interest in population health, health equity, and oncology largely drove my journey from the University of Ibadan to Yale. The Yale School of Public Heath (YSPH), with its strong focus on epidemiology and global health, seemed like the ideal place to expand my skills and knowledge. The program’s commitment to health equity resonated deeply with my goals. For my summer internship, I worked at the Dana Farber Cancer Institute’s Center for Global Health Equity, where I analyzed data to identify the association between family history and prostate cancer risk among African men. Yale helped me develop a clearer understanding of how public health research can influence clinical practice on a global scale. My career has focused on continuing this work—improving patient outcomes and using data to inform strategies in cancer care.

What motivated your shift from clinical dentistry to public health, specifically epidemiology and global health?

My shift from clinical dentistry to public health, particularly epidemiology and global health, was motivated by a combination of experiences that made me realize the need for a broader approach to healthcare. Dentistry allowed me to work closely with patients and provide one-on-one clinical care, which I found deeply rewarding. However, I started noticing that many of the issues my patients faced were not just clinical, they were tied to larger, systemic challenges in healthcare access and socioeconomic factors. Many patients presented with advanced stages of cancer, conditions that could have been managed or prevented with better systems in place. It became clear that the problem was not just about treating individual cases but addressing the systemic issues that led to late-stage diagnoses and poor outcomes.

You’ve explored the role of digital health technologies in cancer screening. How do you envision these tools transforming cancer detection and treatment, especially in underserved populations?

Digital health technologies have the potential to transform cancer care, especially for underserved populations where barriers such as limited healthcare access can delay early diagnosis. These tools can be very efficient in delivering crucial health education on cancer prevention and generate reminders for cancer screenings. For example, I designed, developed, and pilot-tested a tool to educate patients with low health literacy about lung cancer screening. It effectively improved knowledge about lung cancer screening, demonstrating how tailored digital solutions can help bridge knowledge gaps and encourage timely preventive care.

What are the most pressing challenges in cancer treatment in Nigeria, and what strategies would you recommend for addressing them?

The most pressing challenges in cancer treatment in Nigeria presently range from late diagnosis, and limited access to specialized care, to a lack of public awareness about cancer prevention and control. To address these issues, I believe we need to strengthen cancer registries to track disease prevalence, expand community outreach programs to educate the public, and invest in training more healthcare professionals in oncology. Building partnerships between the public and private sectors would also help improve access to cancer care across the country.

Your work on genetic variants and early-onset breast cancer across different populations is fascinating. What are the implications of these findings for public health policies and clinical care?

Firstly, these findings highlight the need for routine genetic testing for early-onset breast cancer, especially in at-risk groups. This testing will help identify individuals who may benefit from early treatment and preventive measures. Also, we found differences in cancer risk among various racial and ethnic groups. This shows the importance of ensuring everyone has equal access to genetic testing and care.

You’ve received numerous honors, including the Margaret McNamara Award. How have these accolades shaped your career, and what personal significance do they hold?

Personally, they inspire me to keep pushing forward and doing my best. It is also a reminder of how far I have come and the impact that can be made through hard work and dedication.

What obstacles have you encountered as a Nigerian researcher and professional in the diaspora? How have you overcome them?

 Navigating a career as a researcher in the diaspora has come with its own set of challenges. From adjusting to different research environments to overcoming cultural barriers. However, I have found strength in the resilience of my community and the support of mentors who have encouraged me along the way. I have also learned the importance of staying focused on the bigger picture—improving healthcare outcomes.

What are your long-term aspirations in public health and oncology? How do you plan to continue making a difference for underserved populations globally?

My long-term goal is to continue driving change through data-driven strategic solutions in the oncology space, as well as advancing health equity. I believe that data plays a crucial role in identifying disparities in cancer care and outcomes, enabling us to develop targeted interventions that can effectively address these gaps.

What advice would you give to young Nigerians who aspire to make a global impact?

My advice would be to stay curious, and recognize the unique value you bring. Seek out opportunities that challenge you, as the world needs more young Nigerians contributing to global solutions. With determination and hard work, there is no limit to what you can achieve.

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